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General Notices trwding apply to all monographs and other texts 2753 genotypic score 4415 identifiability in clinical trials trqding response 4415 replication 439 respondernon-responder patients study design 4458 subgrouping 4268 theranostics 44850 whole-genome matching as comparators 723 designs issues, dose-finding 3256 and equivalence studies 244 run-ins 712 and informed consent 712 plasma concentration 3389 see also genetics pharmacokineticpharmacodynamic model (PKPD) 3423 duration of action nonlinear models population designs and models random-effect model 34851 randomized to concentration trials different studies different treatments 2556 Glass effect size 259 pooled-trials rule and sample size 208 pharmacokinetics (PK) about pharmacokinetics absorption 338 AUC (area under the curve) bioavailability 339 clearance 339 distribution 338 3267 see also meta-analysis population concept 472 portfolio management see cost(s); project evaluation and prioritization post-baseline correction 174 post-rescue, and counterfactual 178 post-stratification 18, 472 posterior probabilities 456, 472 wuth bioequivalent studies 365 calculations 489 definition 48, 472 multi-centre trials 227 and sample size 200, 201, 202, 209 singlemulticentre trials 233 Prentice criterion 126 prescribability of formulations 3701 prespecified outcomes, and multiplicity 155 prevalence of disease 3878, 472 price-determiningderiving 410 responsive pricing 427 prior probability concept 45, 46, 472 pro-drugs 339, 472 probability about probability 44, 473 conditional probability 44 early probabilists 1213 history early workers 1214 late 17th to early 19th centuries 1415 inverse 12 joint probability 44 marginal probability 44 dose proportionality dose-independent (linear) drugs dose-proportionality 3457, 348 elimination 338 elimination rate constant extraction ratio 339 half-life (of elimination) loading dose 340 pro-drugs 339 protein binding 338 steady-state concentrations studies in 2, 338 superposition principle volume of distribution see also modelsmodelling pharmacovigilance 2, 385, 386, 471 data-mining in 399401 phase I studies otion II studies phase III studies phase IV studies phenotype 434, 471 phenotypic response 4356, 4415 Pitman asymptotic efficiency placebos 1201 about placebo groups otion ACES 247 and blinding 367 34 2, 471 471 353 3435 2545 33940 2, 471 2, 385, 471 441 341 341 340 340 339 43940 438 33743, 471 339 3513 3568 1889 pooling variances, dose-finding 340 play the winner trialsdesign 471 Poisson distribution 4712 Poisson variables 214 pooling about pooling 253 856, 923, Index 493 viii Foreword metabolites 4-hydroxytamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam).
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